LADIES LEUKEMIA LEAGUE
RESEARCH GRANT RECIPIENTS
1971-2003





1971-72 Charity Hospital $4,000.00
1972-73 Leukemia Society
Leukemia Trust Fund
$2,500.00
1974 Kathy McDaniel $350.00
Leukemia Society $3,233.66
Children's Hospital $590.00
Dr. William Barrios $2,500.00
Leukemia Society $1,244.52
Edgar Hull, M.D. $1,315.00
M.D. Anderson $1,500.00
1975 Jensie H. Tou $1,900.00
Dr. Robert Gallo $550.00
1976-77 Louisiana Cancer Center $500.00
1979 LSU Dept. of Pediatrics $1,100.00
Leukemia Society $1,972.00
Leukemia Society $3,000.00
1979-80 Leukemia Society $3,000.00
1980-81 Leukemia Society $4,980.00
1981-82 Leukemia Society $9,185.31
1981 Tulane $21,000.00
LSU $6,000.00
1981-83 Children's Hospital $13,000.00
1983 Dr. Schor $4,200.00
1983 Dr. S.H. Leech $4,490.00
1985-1989 Dr. Stephen P. Squntie
LSU
$17,500.00
Project: Human Recombinant Tumor Necrosis Factor Induction of Differentiation of Acute Lymphoblastic Leukemia Cells.

Dr. Emile Freireich
M.D. Anderson
$50,616.00
Project: Autologous Natural Killer (NK) Cell Therapy of Leukemia

Dr. Deborah A. Abertnathy
Tulane
$19,203.00
Project: In Vitro Effects of Retinoids and Recombinant Growth Factors on Normal and Myelodysplastic (Pre-leukemia) Hemopoietic Precursors and its Clinical Significance.


1989-90 Dr. Barbara Beckman
Tulane
$10,000.00
Project: Nuclear events in Leukemia Cells.


1990-92 Dr. Hung Yuen Yeh
LSU
$21,383.00
Project: The Usefulness of Soluble Interleukin-2 Receptor, Soluble CD8 Antigen and Protein Kinase C Activity in Childhood Acute Lymphoblastic Leukemia.
Comment: Seven patients with acute lymphoblastic leukemia were entered on the study and have been followed up for a minimum of 15 months and a maximum of 24 months.

A manuscript has been written on the first five patients and submitted for publication.

Dr. R.P. Warrier
LSU
$30,000.00
Project: Research of childhood leukemia.

Dr. Albert Desserath
M.D. Anderson
$50,000.00
Project: Moleculr Approaches to the Therapy of Leukemia
Comment: Published in The Journal of Biological Chemistry.

Dr. James R. Jeter
Tulane
$21,200.00
Project: Molecular Events in the Regulation of Hematopoiesis

Dr. Cindy Leissenger
Tulane
$21,660.00


1993-94 Dr. Marion Feistadt
LSU
$20,764.00
Project: A Simple and Novel Protocol to Identify the HTLV-1 Cell Surface Receptor.
Comment: Received a grant from the Cancer Association of Greater New Orleans to continue project.


1994-95 Dr. Wayne Vedecksi
LSU
$23,000.00
Project: "Characterization of p90, a new marker for acute Promyelocylic Leukemia".
Comment: "We have succeeded in implementing the RT-PCR assay for acute promyelocytic leukemia (APL) in our lab. We have followed an APL patient for two years, and the assay results agree with the clinical course of the disease".

Dr. Laura Levy
Tulane
$22,500.00
Project: Molecular Determinants of Lymphoid Malignancy
Comment: This project appeared in four publications, including the Journal of Virology and the International Journal of Cancer.

Dr. David J. Carr
LSU
$20,959.00
Project: Aberrant Regulation of Cytokines in HIV-1 TAT72 Transgenic Mice.
Comment: Published in The Journal of Immunology.

Dr. Michael Andreeff
M.D. Anderson
$20,800.00
Project: Leukemia
Comment: The result of this project was presented at the Annual Meeting of the American Society of Hematology. This project was published in the Blood Journal


.
1995-96 Dr. Ronald Luftig
LSU
$23,200.00
Project: Actin Cytoskeleton in Leukemia Virus Morphogenesis
Comment: This abstract was presented at the Annual Meeting of the American Society for Virology.

Dr. Rene Gardner $29,000.00
Project: Long-Term Hemopoietic Injury Induced by Chemotherapy

FILE MISSING $31,700.00


1996-97 Dr. Madeleine Duvic
Univ. of Texas-Houston
$37,500.00
Project: Pathenogeneis of Sezary Syndrome
Comment: This project was published in The Journal Blood.

Dr. Jiandong Chen
LSU
$21,995.00
Project: The Proleolytic Cleavage of the md m 2 Oncogene Product Dureng p52 mediated Apoptosis.

Dr. Maria Velez-LSU $24,000.00
Project: Efficacy of Corticosteroid Treatment in Primary and Relapse Leukemia Patients: Role of Glucocorticoid Receptor Gene.
Comment: Collaborating with the University of Mississippi and Children's Hospital in Los Angeles, Michigan and Tampa.

Dr. Barbara Beckman
Tulane
$14,800.00
Project: The Molecular Mechanism of Multidrug Resistance in Leukemia.
Comment: This project appeared in two journals.


1997-98 Dr. Eric S. Johnson
Tulane
$40,540.00
Project: Detection of Avian Leukosis/Sarcoma Viruses (ALSV) in the Genome of Human Leukemia and Lymphoma Tumor Cells.
Comment: As a result of the preliminary findings he recently was awarded a two-year grant from the NIH.

Jorge Cortes, M.D.
M.D. Anderson
$42,800.00
Project: Immune Recognition OF p210 Cra/Abl in Patients with Chronic Myelogenous Leukemia.
Comment: Significant progress in the identification of specific immune recognition of p210 BCR/ABL, both by cellular and humoral mechanisms, and correlation with response to Interferon treatment.

Dr. Paul Schwarzenberger
LSU
$19,880.00
Project: Development of a gene therapy based bone marrow purging system for leukemia patients.


1998-99 David Good, M.D.
LSU
$30,000.00
Project: Selective Targeting of Hematopoietic Stem Cells via the c-kit Receptor.

Patricia D. Castro, Ph.D. and Lalitha Nagarajan, Ph.D
M.D. Anderson
$33,000.00
Project: Deletions of chromosome 5Q 13.3 and 17p loci cooperate in myeloid neopla.
Comment: Received honorable mention in the Bristol-Myers Squibb Award in Clinical/Translational Science. This project was published in the March 1999 issue of BLOOD JOURNAL. Applied for an $800,000 federal grant on this project. The review is quite favorable.

Chris Theodossiou, M.D.
LSU
$45,540.00
Project: Investigation of IL 17 in Patients with Bone Marrow Failure.

Laura Levy, Ph.D. $19,500.00
Project: Role of the Immune Environment in the Development of Lymphoma.
Comment: The results were published in a manuscript by Beaty, R.M., K. Rulli, L. Bost, J. Pantginis, J. Lenz and L.S. Levy, L99 high levels of Il-4 and 11-10mRNA and low levels of Il-2 and IFN-Yymrna in MuL V-induced lymphomas. Published in GENE (An International Journal on Genes, Genomes and Evolution): Identification and analysis of a third mouse Polycomb gene MPC3. Received additional funding from American Cancer Society and Development Funds from the Tulane Cancer Center.


1999-2000 Marina Konopleva, M.D. Ph.D.
M.D. Anderson
$58,724.00
Project: Therapy of AML.
Comment: Submitted to NCI. Preliminary results obtained have assisted in being awarded the W.M. Keck Foundation Grant at the University of Texas, M.D. Anderson Center "Anti-apoptotic Protein Survivin as a New Target in AML Therapy". The research conducted under this grant award also assisted in renewing an NCI grant award.

Charles S. Hemenway, M.D., Ph.D.
Tulane
$10,000.00
Project: Analysis of a third mouse Polycomb gene, MPc3
Comment: Paper published in GENE (An International Journal on Genes, Genomes and Evolution) on protocol Identification and Analysis of a Third Mouse Polycomb gene, MPc3.

Kevin D. Brown, Ph.D.
LSU
$34,550.00
Project: ATM KINANSE DOMAI
Comment: This project was submitted to the journal Biotechniques. A grant request was made to NIH for this project. This project established a new avenue of investigation (colon cancer gene). A manuscript is being published at this time.


2000-2001 Richard H. Scheurmann, Ph.D
UT Southwest Medical Center, Dallas
$49,500.00
Project: Targeting Peptides for T-Cell Acute Lymphoblastic Leukemia Therapy.
Comment: Seeking additional funding to continue the project.

Guillermo Garcia-Manero, M.D
M.D. Anderson
$40,000.00
Project: "Post-remission immunotherapy of acute myelogenous leukemia with an autologous dinitrophenyl (DNP)-modified leukemia cell vaccine".
Comment: This study has allowed us to better understand the theraputic needs of patients with advance AML and potentially develop similar programs for patients in first remission or after allogeneic bone marrow transplantation.

Reeves Huie, Ph.D.
M.D. Anderson
$35,000
Project: Evaluation of Plasma 5-Oxoprolime as a Convenient Marker of Apoptosis in Leukemia
Comment: Grant funds were returned. Dr. Huie left M.D. Anderson before project was started.


2001-2002 Francesco Onida, M.D.
M.D. Anderson
$30,000.00
Project: Development of New Combination Therapies for Philadelphia Chromosome Positive Leukemia
Comment: Submitted project to the Cancer publication. Result of this study was presented at the Annual Meeting of the American Society of Hematology.

Renee V. Gardner, M.D.
LSU
$29,742.00
Project: A Study of Rasayanas as a Cardioprotectant Agent Through Antioxidation

Laura Levy, Ph.D.
Tulane
$34,989.00
Project: Clinical and Laboratory Predictors of Lymphoma in the Nonhuman Primate Model.

Angus McLeod Sinclair, Ph.D.
UT, Dallas
$35,000.00
Project: Role of Transcriptional Repressor CDP in myeloid Leukemia.

Li Li, M.D. Ph.D.
Ochsner
$30,000.00
Project: Stromal Cell Molecules Required for Malignant-B Cell Tumor Generation in Vivo.


2002-2003 Dr. Bing Z. Carter
M.D. Anderson
$35,000.00
Project: "Target Antiapoptotic Survivin in Acute Myelogenous Leukemia."

Laura Levy, Ph.D.
Tulane
$35,000.00
Project: Growth Regulations of SAIDS-Associated Lymphomas

Dr. Srdan Verstovsek
M.D. Anderson
$30,000.00
Project: "Targeted Anti-Angiogenesis Therapy of Myeloid Bone Marrow Diseases."

Dr. Mansour Mohamadzadeh
Tulane
$30,000.00
Project: Development of a Novel Il-15 Based Vaccine to Treat Cutaneous T Cell Lymphoma.
Dr. Yan Cui
LSU
$30,000.00
Project: Empower the Immune System to Combat Leukemia: Combination Immunotherapy of Targeting Tumor Antigen to Dendritic Cella and GM-CSF Enchanced Antigen Presentation.


2003-2004 Seth J. Corey, M.D. MPH
M.D. Anderson
$30,000.00
Project: "siRNA Tareting of Lyn Tyrosine Kinase in Acute Leukemia"

Bulent Ozspolat, M.D., Ph.D.
M.D. Anderson
$32,500.00
Project:"Identification of Novel Molecular Targets in All-Transretinoic Acid (ATRA) Induced Differentiation and Resistance in Acute Promyeloctic Leukemia Through Expression Proteomics Analysis"

Frank C. Marini, Ph.D.
M.D. Anderson
$30,000.00
Project: "Mesenchymal Stem Cells (Stromal Cells) Expressing Interferon as a Targeted Antileukemia Therapy"

Charles S. Hemenway, M.D., Ph.D.
Tulane University School of Medicine
$34,187.00
Project: "Development of a Model of Infant Leukemia for Targeted Therapeutics"


2004-2005 Bing Z. Carter, Ph.D
M.D. Anderson
$35,000.00
Project: "The X-chromosome-linked Inhibitor of Apoptosis as a Therapeutic Target for the Treatment of Acute Myeloid Leukemia"
Laura S. Levy, Ph.D.
Tulane University School of Medicine
$35,000.00
Project: "Novel Retroviruses as Tools for the Discovery of Oncogenes Associated with Lymphoma"
Bo Xu, M.D., Ph.D.
LSU Health Sciences Center
$35,000
Project:"Interfering with DNA Damage Signals: Chemo-sensitizing Leukemia Using Small Peptides"


2005-2006 Erik K. Flemington, Ph.D.
Tulane Health Sciences Center, Department of Pathology, SL79
$25,000.00
Project:"Identification of EBV regulated cellular genes that contribute to EBV associated lymphomas"
Soung-Chul Cha, Ph.D., M.D
University of Texas, MD Anderson Cancer Center
$25,000.00
Project: "Discovering novel lymphoma antigens as targets for immunotherapy"
Xiao Ni, M.D. Ph.D.
University of Texas, MD Anderson Cancer Center
$25,000
Project:"Induction of Polyclonal T-Cell Responses against Cutaneous T-Cell Lymphomas by Autologous Dendritic Cells Transfected with Amplified Tumor RNA"
Mary Ann Weiser, M.D. Ph.D.
University of Texas, MD Anderson Cancer Center
$25,000.00
Project: "Effects of hyperglycemia and AKT Activation on Chemo Resistance of Blasts from Patients with Acute Lymphocytc Leukemia"
Rui-Yu Wang, M.D., Ph.D.
University of Texas, MD Anderson Cancer Center
$25,000
Project:"The Role of Apoptotic Inducing Factor (AIF) IN Acute Myeloid Leukemia"


2007-2008 Terzah M. Horton, M.D. Ph.D.
Texas Children's Cancer Center, Baylor College of Medicine
$30,000.00
Project:Targeting Pediatric Leukemia Stem Cells to Enhance Treatment Response rates
Marilyn M. Li, M.D.
Tulane University Health Science Center, Hayward Genetics Center
$30,000.00
Project: MLL partial tandem duplications in prenatal tissues and cord blood: Benign Micro-mosaicism or Laten Predisposition
Xin Lin, Ph.D.
University of Texas, MD Anderson Cancer Center, Associate Professor, Department of Molecular and Cellular Oncology
$30,000.00
Project:CARMA 1 (a scaffold molecule) - associated NF-AF activation in diffuse large B cell lymphoma
Om Prakash, Ph.D.
Ochsner Clinic Foundation
$30,000.00
Project: Lyn tyrosine kinase: a novel target in the treatment of B cell chronic lymphoctic leukemia (B-CLL) - the most common leukemia in the western world affecting adults over the age of 60 and remains incurable
Chunlei Zhang, M.D. Ph.D.
University of Texas, MD Anderson Cancer Center, Instructor, Department of Dermatology
$30,000
Project:Selective Antitumor Activity of HDAC Inhibitors in Cutaneous T-Cell Lymphomas: From bench to bedside & back
Michael W. Van Dyke, Ph.D
University of Texas MD Anderson Cancer Center, Department of Molecular and Cellular Oncology
$25,000
Project:A multimodal agent against Acute Myelogenous Leukemia





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LADIES LEUKEMIA LEAGUE